The UK has well-developed sexually transmitted infection (STI) services based in genitourinary medicine (GU) clinics. Nevertheless, non-specialists will encounter STIs, especially in emergency department and primary care settings and need know how to select, perform and interpret tests for common STIs and deal with common problems in a syndromic fashion. Non-specialists should also know about post-exposure prophylaxis for sexual exposure (PEPSE) for HIV and conditions encountered in medical specialities that should lead to the offer of HIV testing. Clinicians working in primary care need to adopt a pragmatic approach to investigation and treatment of STIs as referral is not always practicable.
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