pH and salivary sodium bicarbonate in cancer patients: correlation with seric concentration

• Thais Rojas-Morales ^[1] ; Rita Navas ^[1] ; Ninoska Viera ^[1] ; Carmen Julia Álvarez ^[1] ; Neira Chaparro ^[1]
  1. [1] La Universidad del Zulia

     La Universidad del Zulia

     Venezuela

     
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 13, Nº. 7 (July), 2008
• Idioma: inglés
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• Resumen

  • Objective: To determine the correlation between pH and bicarbonate of soda in blood and saliva in child and adolescent patients during the administration of 3g/m2 of methotrexate. Method: A controlled clinical test was performed on 23 patients diagnosed with Acute Lymphoblastic Leukemia. Ages ranged from 4 to 18. The Spearman Correlation Coefficient was used to interpret the data. Results: No significant correlation was found between pH levels and seric and salivary sodium bicarbonate. However, there was a significant correlation between the levels of sodium bicarbonate in the body fluids evaluated (rs 0.2576, p=0.0354). Conclusions: Changes modifying the microenvironment of the oral cavity probably do not allow saliva to be used to determine blood pH and seric bicarbonate.