Fibroblast Growth Factor 23–Mediated Bone Disease

Anda R. Gonciulea ^[1] ; Suzanne M. Jan De Beur ^[1]
1. [1] Johns Hopkins University
  
  Johns Hopkins University
  
  Estados Unidos
Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 46, Nº. 1, 2017, págs. 19-39
Idioma: inglés
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Resumen
- Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.