Performance Characteristics of the New Definition of Diabetes: The Insulin Resistance Atherosclerosis Study

• Autores: Carlos Lorenzo, Steven M. Haffner
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 33, Nº. 2, 2010, págs. 335-337
• Idioma: inglés
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• Resumen

  • A1C ≥6.5% has been recently proposed as the defining criterion for diabetes. However, performance characteristics of this definition have not been described. In the Insulin Resistance Atherosclerosis Study, we compared new to previous definitions of diabetes: 1999 World Health Organization (DM^sub 1999WHO^) and 2003 American Diabetes Association based on fasting glucose alone (DM^sub FPG126^). Participants with A1C ≥6.5%, DM^sub 1999WHO^, and DM^sub FPG126^ were 44 (5.2%), 132 (15.4%), and 61 (7.1%), respectively. In individuals with DM^sub 1999WHO^, mean, median, and interquartile range of A1C were 6.3, 5.9, and 5.5-6.6%, respectively; in individuals with DM^sub FPG126^, mean, median, and interquartile range of A1C were 7.0, 6.6, and 6.0-7.1%. A1C ≥6.5% identifies fewer individuals than DM^sub 1999WHO^ or DM^sub FPG126^. Studies are needed to determine that A1C ≥6.5% compromises neither blood pressure and lipid management in early diabetes nor the implementation of lifestyle interventions for diabetes prevention.