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Comparative immunoexpression of ICAM-1, TGF-β1 and ki-67 in periapical and residual cysts

    1. [1] DDS, MSc, Post Graduation. Program in Dentistry, Estácio de Sá University
    2. [2] DDS, PhD, Professor. Post Graduation Program in Dentistry, Estácio de Sá University
    3. [3] DDS, MSc, Professor. Oral Pathology, School of Dentistry, State University of Rio de Janeiro
  • Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 22, Nº. 1 (Enero), 2017
  • Idioma: inglés
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  • Resumen
    • This study compared the immunohistochemical expression of ki-67, transforming growth factor beta 1 (TGF-β1) and intercellular adhesion molecule-1 (ICAM-1) in inflammatory periapical cysts and residual cysts.

      The study sample was composed by 25 periapical cysts and 25 residual cysts and immunohistochemical reactions were carried out using antibodies directed against ICAM-1, TGF-β1 and ki-67. Clinical, radiological, gross, histological and immunohistochemical data were tabulated for descriptive and comparative analysis using the SPSS software and differences were considered statistically significant when p<0.05%.

      There were no differences between the expression of ICAM-1 (p=0.239) and TGF-β1 (p=0.258) when comparing both groups. Ki-67 labeling index was higher in residual cysts compared to periapical cysts (p=0.017).

      Results from the present study suggest that some specific inflammatory stimuli on residual cysts would modulate their mechanisms of etiopathogenesis, growing and repair.


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