Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

• Autores: Alexandra Zhernakova, Alexander Kurilshikov, Marc Jan Bonder
• Localización: Science, ISSN 0036-8075, Vol. 352, Nº 6285, 2016, págs. 565-569
• Idioma: inglés
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• Resumen

  • Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.