Resumen de TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

Rachel Deplus, Benjamin Delatte, Marie K. Schwinn, Matthieu Defrance, Jacqui Méndez, Nancy Murphy, Mark A. Dawson, Michael Volkmar, Pascale Putmans, Emilie Calonne, Alan H. Shih, Ross L. Levine, Olivier Bernard, Thomas Mercher, Eric Solary, Marjeta Urh, Danette L. Daniels, Francois Fuks

• This paper identifies the N-acetylglucosamine transferase OGT as binding partner for TET2/3 proteins. Their genome-wide chromatin binding and the characterization of the Set1/COMPASS complex as OGT target implies coordinated gene regulation.