Resumen de Associations of Objectively Measured Physical Activity and Abdominal Fat Distribution.
Annelotte Philipsen, Daniel R Witte, Anne-louise Smidt Hansen, Annelli Sandbaek, Marit Eika Jorgensen, Bendix Carstensen, Soren Brage, Thomas Peter Almdal, Torsten Lauritzen, Erling Bjerregaard Pedersen, Jeppe Gram
AB Introduction/Purpose: Visceral adipose tissue (VAT) and physical activity are both independent predictors of Type 2 diabetes. Physical activity and overall obesity are inversely associated with each other. Yet the nature of the association between objectively measured dimensions of physical activity and abdominal fat distribution has not been well characterized. We aimed to do so in a middle-age to elderly population at high risk of diabetes. Methods: A cross-sectional analysis of 1134 participants of the ADDITION-PRO study. VAT and subcutaneous adipose tissue (SAT) were assessed one-dimensionally by ultrasonography and physical activity with combined accelerometry and HR monitoring. Linear regression of physical activity energy expenditure (PAEE) and time spent in different physical activity intensity levels on VAT and SAT was performed. Results: Median body mass index (BMI) was 26.6 kg[middle dot]m-2 and PAEE was 28.1 kJ[middle dot]kg-1[middle dot]d-1, with 18.9 h[middle dot]d-1 spent sedentary, 4.5 h[middle dot]d-1 in light-intensity physical activity, and 0.4 h[middle dot]d-1 in moderate-intensity physical activity. PAEE was significantly negatively associated with VAT, and in women, PAEE was also significantly negatively associated with SAT. The difference in VAT was -1.1 mm (95% confidence interval [CI] = -1.8 to -0.3) per 10-kJ[middle dot]kg-1[middle dot]d-1 increment, and the corresponding difference in SAT for women was -0.6 mm (95% CI = -1.2 to -0.04) in models adjusted for age, sex, and waist circumference. Exchanging 1 h of light physical activity with moderate physical activity was significantly associated with VAT (-4.5 mm, 95% CI = -7.6 to -1.5). Exchanging one sedentary hour with light physical activity was significantly associated with both VAT (-0.9 mm, 95% CI = -0.1 to -1.8) and SAT (-0.4 mm, 95% CI = -0.0 to -0.7). Conclusions: In this population with low physical activity levels, cross-sectional findings indicate that increasing overall physical activity and decreasing time spent sedentary is important to avoid the accumulation of metabolically deleterious VAT
