Histone Deacetylase Inhibitors for Cutaneous T-Cell Lymphoma

• Autores: Madeleine Duvic
• Localización: Dermatologic clinics, ISSN 0733-8635, Vol. 33, Nº. 4, 2015 (Ejemplar dedicado a: Cutaneous Lymphoma), págs. 757-764
• Idioma: inglés
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• Resumen

  • Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin’s T-cell lymphomas that present as skin lesions. Mycosis fungoides with large cell transformation has a 5-year overall survival of 32% with involved skin and 7% with extracutaneous involvement. Failure to cure advanced MF with large cell transformation and peripheral T-cell lymphoma has resulted in a search for novel targeted agents including antibodies and gene modulators. Histone deacetylase inhibitors are small molecules that seem to be particularly active for T-cell lymphoma.