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Resumen de Increased level of interleukin-13, but not interleukin-4 and interferon-y in chronic rhinosinusitis with nasal polyps

M. Nabavi, S. Arshi, A. Bahrami, Z. Aryan, M.H. Bemanian, H. Esmaeilzadeh, F. Jalali, S.B. Pousti, Nima Rezaei

  • Background This study was performed to investigate the serum level of interleukin (IL)-13, IL-4, and interferon (IFN)-? in chronic rhinosinusitis with nasal polyps (CRSwNP) and subsequent inflammation pattern and comorbidities including asthma and aspirin intolerance.

    Methods A case�control study was conducted on 60 adult patients with CRSwNP with mean age of 37.7 ± 12.7 (ranging from 18 to 70) years, and on 20 healthy controls. Serum levels of IL-13, IL-4, and IFN-? were assessed, using enzyme-linked immunosorbent assay to be compared between case and control groups. Serum level of total immunoglobulin (Ig) E was also assessed in the patients with CRSwNP.

    Results Serum level of IL-13 in the patients with CRSwNP was significantly higher than the controls (0.98 ± 1.56 vs. 0.34 ± 0.16 pg/ml, respectively, p = 0.002). IL-4 and IFN-? did not differ significantly between the two groups. Total IgE level was significantly increased in the patients with CRSwNP, compared to the normal values (301.43 ± 516.54 IU/ml, p = 0.033). Among the patients with CRSwNP, 12/60 (20%) had aspirin intolerance and 44/60 (73.3%) had asthma. IgE was also higher in asthmatics than non-asthmatics patients (364.9 ± 586.6 vs. 126.7 ± 135.7, respectively, p = 0.015). Patients with aspirin intolerance had higher levels of IFN-? (4.7 ± 1.4 vs. 4.1 ± 0.6, respectively, p = 0.022).

    Conclusions IL-13 with high level of total IgE was observed in the patients with CRSwNP, which predisposes them to have concomitant asthma. IFN-? seems to be down-regulated in the patients with CRSwNP, but could be over-expressed in the presence of aspirin intolerance.


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