Resumen de Burkitt's lymphoma of the jaws in the Amazon region of Brazil
Hélder-Antônio Rebelo-Pontes, Michelle-Carvalho de Abreu, Douglas-Magno Guimarães, Felipe Paiva Fonseca, Bruno Augusto Benevenuto de Andrade, Oslei Paes de Almeida, Décio-dos-Santos-Pinto Júnior, Flávia Sirotheau Corrêa Pontes
Objectives: To describe the clinicopathologic and immunohistochemical features of Burkitt's lymphoma of the jaws in 7 patients of Northern Brazil.
Study Design: Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV).
Results: Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease.
One young adult patient refused treatment and died 3 months after initial diagnosis.
Conclusions: Burkitt's lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinicopathologic features to those described in endemic areas of Africa, including EBV positivity.
