Medicamentos que prolongan el intervalo QT

• Autores: David Berlana, Eduard Fort Casamartina, Ramón José Jódar Masanés
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 4, Nº. 6, 2002, págs. 410-418
• Idioma: español
• Títulos paralelos:
  • Medication that prolongs the QT interval
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• Resumen

  • There exist several definite situations that may predispose one to suffer a prolongation of the QT interval (QTI), like that of specific patients with a congenital prolongation of the QTI, the existence of cardiovascular illnesses, clinical situations that are characterized by episodes of electrolytic imbalance, bradycardia, etc. As well, there exist numerous communications in the scientific literature that relate drug without antiarrhythmic action per se administering to QTI prolongation to Torsades de Pointes (TdP) episodes and to sudden death cases. A review of the available literature has taken place regarding cases of QTI prolongation and TdP episodes related to non-antiarrhythmic drug administering. Prudence advises that before initiating a drug therapy that may affect the QT interval, there be an evaluation of the risk/benefit equilibrium as well as of the possible therapeutic alternatives.