Linus Pauling, working on the protein from another angle, discovered that the hemoglobin of people with sickle cell anemia (HbS) was structurally different from that of healthy individuals. Sickle cell anemia became "one of the first examples of a genetic disease," says Anthony Cerami, PhD, who contributed to the development of HbAlc as a clinical marker. [...]based on the advice of his mentor, Rahbar returned to Iran to establish such a research program.
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