Development of antigen cross-presentation capacity in dendritic cells

• Autores: Christiane Dresch, Yann Leverrier, Jacqueline Marvel, Ken Shortman
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 33, Nº. 8, 2012, págs. 381-388
• Idioma: inglés
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• Resumen

  • Cross-presentation by dendritic cells (DCs) of exogenous antigens on MHC class I is important for the generation of immune responses to intracellular pathogens, as well as for maintenance of self tolerance. In mice, the CD8+ DC lineage is specialised for this role. However, DCs of this lineage are not born with cross-presentation capacity. Several studies have demonstrated that it must be induced as a later developmental step by cytokines such as granulocyte macrophage colony-stimulating factor (GM-CSF), or by microbial products such as toll-like receptor (TLR) ligands. Increased cross-presentation capacity is thus induced in peripheral CD8 lineage DCs during inflammation or infection. However, this capacity is already fully developed in steady-state thymic CD8+ DCs, in accordance with their role in the deletion of self-reactive developing T cells.