A twist of insight - the role of Twist-family bHLH factors in development
- Autores: Ralston M. Barnes, Anthony B. Firulli
- Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 53, Nº. 7, 2009, págs. 909-924
- Idioma: inglés
- Enlaces
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Resumen
Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential developmental programs. Twist-family bHLH proteins function by dimerizing with other bHLH members and binding to cis- regulatory elements, called E-boxes. While Twist-family members may simply exhibit a preference in terms of high-affinity binding partners, a complex, multilevel cascade of regulation creates a dynamic role for these bHLH proteins. We summarize in this review information on each Twist-family member concerning expression pattern, function, regulation, downstream targets, and interactions with other bHLH proteins. Additionally, we focus on the phospho-regulatory mechanisms that tightly control posttranslational modification of Twist-family member bHLH proteins.
