Influencia del estatus de cobre sobre la acumulación de metales tóxicos y esenciales en ganado vacuno.

• Autores: María Marta López Alonso, Joaquín Hernández Bermúdez, José Manuel Cruz López, Cristina Castillo Rodríguez, Isabel Blanco Penedo, José Luis Benedito Castellote, M. Miranda
• Localización: Revista de toxicología, ISSN 0212-7113, Vol. 22, Nº. 3, 2005, págs. 200-204
• Idioma: español
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• Resumen

  • Interactions between toxic and essential metals, as well as among essential metals themselves, can modulate their accumulation and toxicity. In this study, correlations between copper and toxic (cadmium, lead) and essential elements (molybdenum, iron, selenium, zinc, manganese and cobalt) were evaluated in tissues (liver, kidney) of 195 calves from the region of Deza (NW of Spain), where there is intensive pig farming and the animals usually have high hepatic copper concentrations. Metal concentrations were determined by ICP-OES, and correlations between pairs of elements were determined from Spearman rank correlations. Our results indicated that the high copper exposure in calves in the region of Deza lead to a higher hepatic lead deposition, a lower cadmium accumulation in liver, and a lower cadmium accumulation in the kidney. In relation to the essential elements, the positive association among copper, molybdenum, iron and zinc indicate that the high copper exposure in our animals does not have an antagonistic effect on these essential elements that is directly related to copper status. On the contrary, the association between copper and selenium could indicate that animals exposed to high copper levels are suffering oxidative damage, or alternatively, the potential role of selenium on copper accumulation in the liver.