Resumen de Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats
Emilia María Carmona Calero, Herminia Calixta Pérez González, I. Martínez-Peña Valenzuela, Ibrahim González Marrero, Carlos Gustavo Pérez García, Norberto Marrero Gordillo, José Carlos Ormazábal Ramos, Agustín Lorenzo Castañeyra Perdomo, Romualdo Ferres Torres
Summary. We studied the effects of spontaneous high blood pressure and the captopril treatment on the subfornical organ (SFO) of rats. The brains of control Wistar-Kyoto rats (WKY), WKY rats treated with captopril (WKY-T), spontaneously hypertensive rats (SHR) and SHR rats treated with captopril (SHR-T) were processed immunohistochemically using anti-angiotensin II as primary antibody. Immunorective material (IRM) for angiotensin II was observed in a group of neurons and some cells of the ependymal layer of the SFO in WKY rats. The angiotensin II immunoreactive (AGII-ir) in the SHR rats was decreased, showing positive reaction only in a few neurons, while captopril treatment induced an increase in immunoreactive material in hypertensive rats, but contrarily, the expression of AGII-ir in the WKY-T group was scarce. The variations of the angiotensin II observed in the SFO could be owing to an interaction between the hypertension and its captopril treatment. Histol Histopathol 20, 135-138 (2005)
