Publication: Virus Linfotrópico de Células T Humano tipo 1 (HTLV-1) como Agente Etiológico de la Leucemia-Linfoma de Células T del Adulto (LLTA) : epidemiología, Transmisión y Prevención en América Latina
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2022-03-31
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Universidad Complutense de Madrid
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Abstract
El Virus Linfotrópico de Células T Humano tipo 1 (HTLV-1) fue el primer retrovirus considerado como agente etiológico de una neoplasia humana: la Leucemia-Linfoma de Células T del Adulto(LLTA). También es el agente causal del trastorno neurológico progresivo Paraparesia Espástica Tropical/Mielopatía Asociada al HTLV-1 (PET/MAH). Además, los pacientes infectados por HTLV-1 tienden a tener formas más graves de algunas enfermedades infecciosas como la estrongiloidiasis y la tuberculosis. Las regiones endémicas de HTLV-1 incluyen Japón, África subsahariana, América del Sur, la región del Caribe, Australo-Melanesia y algunas zonas de Oriente Medio. Se estima que aproximadamente entre 5 y 10 millones de personas están infectadas con HTLV-1 en todo el mundo, aunque este número podría ser mucho mayor debido a la falta de estudios epidemiológicos en algunas áreas. Con el objetivo de sintetizar la vasta información sobre el HTLV-1 y la LLTA en América Latina, y ala vez, desarrollar estrategias preventivas adaptadas a las peculiaridades socioeconómicas de la región, se realizó una revisión integradora, basada en la búsqueda sistemática de la bibliografía, de acuerdo con el esquema PRISMA. Con la información publicada sobre la prevalencia de HTLV-1, LLTA yPET/MAH, elaboramos mapas y tablas de los estudios seleccionados, y desarrollamos un algoritmo de prevención de la transmisión del HTLV-1 a través de la lactancia materna, considerando el estatus socioeconómico...
HTLV-1 was the first retrovirus considered responsible of a human cancer: Adult T Cell Leukemia-Lymphoma (ATLL). It also causes Tropical Spastic Paraparesis/HTLV Associated Myelopathy(TSP/HAM), a progressive neurological disorder. Besides, infected patients tend to have more severe forms of infectious diseases such as strong yloidiasis and tuberculosis. Endemic HTLV-1 regions include Japan, sub-Saharan Africa, South America, the Caribbean area, Australo-Melanesia and some Middle East spots. Approximately 5–10 million people are known to be infected with HTLV-1worldwide, although this number may be much higher due to lack of epidemiological studies in some areas.In order to synthesize the vast information on HTLV-1 and ATLL in Latin America and at the sametime, develop preventive strategies adapted to the socioeconomic peculiarities of the region, an integrative review was performed, based on a systematic bibliographic search according to the PRISMA scheme. With the published information on the prevalence of HTLV-1, ATLL and TSP/HAM, we present complete and accurate maps and tables of selected studies...
HTLV-1 was the first retrovirus considered responsible of a human cancer: Adult T Cell Leukemia-Lymphoma (ATLL). It also causes Tropical Spastic Paraparesis/HTLV Associated Myelopathy(TSP/HAM), a progressive neurological disorder. Besides, infected patients tend to have more severe forms of infectious diseases such as strong yloidiasis and tuberculosis. Endemic HTLV-1 regions include Japan, sub-Saharan Africa, South America, the Caribbean area, Australo-Melanesia and some Middle East spots. Approximately 5–10 million people are known to be infected with HTLV-1worldwide, although this number may be much higher due to lack of epidemiological studies in some areas.In order to synthesize the vast information on HTLV-1 and ATLL in Latin America and at the sametime, develop preventive strategies adapted to the socioeconomic peculiarities of the region, an integrative review was performed, based on a systematic bibliographic search according to the PRISMA scheme. With the published information on the prevalence of HTLV-1, ATLL and TSP/HAM, we present complete and accurate maps and tables of selected studies...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 22-07-2021