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http://hdl.handle.net/10347/16134
Título: | Forensic Ancestry Analysis with Autosomal Polymorphisms
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Autor/a: | Phillips, Christopher Paul
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Dirección/Titoría: | Carracedo Álvarez, Ángel (dir.)
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Centro/Departamento: | Universidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía Universidade de Santiago de Compostela. Instituto de Ciencias Forenses Luís Concheiro Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría
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Palabras chave: | Inferencia de Ancestralidad / Ancestry inference | Análisis forense de ADN / Forensic DNA analysis | Genética de poblaciones / Population genetics | Polimorfismo nucleótido único/Single nucleotide polymorphism | |
Data: | 2017
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Resumo: | The inference of ancestry from biological material left at a crimescene has been a longstanding but specialised forensic technique, often lacking sufficient detail to make a reliable inference of ancestr y. This thesis describes the key steps in developing a forensic ancestry test that can be adopted by
any laboratory using capillary electrophoresis equipment: optimisation of a PCR multiplex to detect
DNA markers from contact traces; compilation of population data from which to infer the likely pop ulation of origin of the person; detection of coancestry patterns in an individual with admixed backgr ounds; and development of online statistical tools that calculate the probability of an individual’s an cestry from a submitted SNP profile. Additional types of autosomal markers were compiled from Ind el polymorphisms; short tandem repeats (STRs); multiple allele SNPs; and Microhaplotype markers. |
URI: | http://hdl.handle.net/10347/16134
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Dereitos: | Esta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl
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