Rh(III)-catalyzed annulations based on C-H activation. Sustainable synthesis of carbo- and heterocycles
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http://hdl.handle.net/10347/14933
Título: | Rh(III)-catalyzed annulations based on C-H activation. Sustainable synthesis of carbo- and heterocycles
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Autor/a: | Seoane Fernández, Andrés
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Dirección/Titoría: | Mascareñas Cid, José Luis
Gulías Costa, Moisés
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Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
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Palabras chave: | Organometallic chemistry | catalysis | C-H activation | annulations | |
Data: | 2016
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Resumo: | One of the main challenges still present within organic synthesis is the ability to achieve
complex molecules with high efficiency. In this context metal-catalyzed C-H functionalization
processes have gained a lot of attraction due to their ability to increase molecular complexity
in few steps and with a minimum generation of waste. These kind of reactions occurs through
a metallacyclic intermediate which can be trapped with a huge variety of unsaturated products
by a cycloaddition step. This combination of C-H activation and cycloaddition allows to obtain
cyclic structures in few steps and high yields. The work realized within my PhD period
embraces the field of C-H activation through the development of novel reactivity patterns in
Rhodium (III)-catalyzed oxidative annulation reactions. These processes allow to obtain
interseting biological and/or biomedic compounds with a high atom and step economy from
simple comercial precursors. |
URI: | http://hdl.handle.net/10347/14933
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Dereitos: | Esta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl
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