Immunisation of rabbits with house dust mite extract does not protect against infection by Graphidium strigosum

• Autores: Montserrat Cuquerella Ayensa, E. M. Fawzi, R. Paramio, José María Alunda Rodríguez
• Localización: Revista Ibero-latinoamericana de parasitología, ISSN 0718-8730, Vol. 70, Nº. 1, 2011, págs. 58-64
• Idioma: inglés
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• Resumen

  • The effect of prior immunisation of rabbits with house dust mite extract (DpSE) on the challenge with 750 L3 of Graphidium strigosum, and the effect of immunisation with DpSE on a chronic gastric infection of rabbits with G. strigosum were studied. Immunisation did not provoke any signifi cant variation in the haematological (packed cell volume, leukocyte and eosinophil counts) and parasitological (prepatency period, parasite egg output and parasite burden) parameters determined in the infected rabbits. However, immunisation with DpSE elicited a signifi cant increase in IgG levels against both DpSE and G. strigosum soluble extract (ASE Gs). Higher levels of circulating anti-ASE Gs antibodies in immunised rabbits with a chronic helminth infection could be related to the cross-reactivity between DpSE and ASE Gs (ELISA and Western blotting).