The general scientific methodological conception of Intensive Multifactorial Neurorehabilitation System is presented here. This issue has been applied at CIREN, starting from its practical application 16 years ago. More than 16,000 chronic patients from more than 70 countries, have been assisted at CIREN of different neurologic diseases. Origins, historical antecedents, update techniques, scientific methodological bases, general objectives and composition of rehab teams, explain the intensive character of its application. The program has statistically reflected its specialty during the last 5 years. Obtained results are shown in the different treated groups of patients. This scientific methodological conception and general organization of this issue, has permitted us for over 16 years to improve the quality of life of over 16,000 patients assisted at our center. CIREN's medical staff has stated that the use of the Intensive Multifactorial Neurorehabilitation System permits the chronic patients to recover a greater number of lost functions in less time than with the use of conventional forms of neurological rehabilitation, that require longer periods of time.